Multiparticulate system is one of the most widely accepted technologies in the pharmaceutical industries. The present study aims to prepare controlled release multiparticulates of Zidovudine by Solution / suspension layering technique using two different release retardants (Eudragit RS-100 and Eudragit RL-100, and their combination) in three different release retardant concentrations (10%, 20%, 30%). This method involves the deposition of successive layers of solution and/or suspensions of drug substances and binders on starter seeds. In principle, the factors that control coating processes apply to solution or suspension layering. The prepared multiparticulates were evaluated for friability, drug content uniformity, micromeritic property, density and percentage yield. The release rate was evaluated by dissolution studies. FT-IR was done to establish drug polymer compatibility. Study concluded that solution and/or suspensions layering of Zidovudine can be effectively used for drug loading on non-pareil seeds. FT-IR study concluded that there is no interaction between Zidovudine, Eudragit RS-100 and Eudragit RL-100. It was also found that formulation having Eudragit RS-100 have more retarding capacity with drug than the Eudragit RL-100 in both formulations and shows promising result. From dissolution parameter of the prepared multiparticulates it is concluded that formulation A8 possesses the required characteristics of oral controlled release formulation.
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